黑龙江11选5

中西医药Chinese and Western Medicine
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雷贝拉唑钠肠溶胶囊(济诺)

【成 份】:雷贝拉唑钠 化学名称:2-[[[4-(3-甲氧基丙氧基)-3-甲基-2-吡啶基]甲基]亚磺酰基]-1H-苯并咪唑钠。
【性 状】:本品为肠溶胶囊,内容物为类白色或微黄色颗粒或粉末。
【功能主治】:

  1、活动性十二指肠溃疡;

  2、良性活动性胃溃疡;
  3、伴有临床症状的侵蚀性或溃疡性的胃-食管反流征(GERD);
  4、与适当的抗生素合用,可根治幽门螺旋杆菌阳性的十二指肠溃疡;
  5、侵蚀性或溃疡性胃-食管反流征的维持期治疗,目前疗程超过12个月的药效尚未进行评估。




【规    格】(1)   10mg  (2) 20mg

【YONGFAYONGLIANG】

黑龙江11选5     BENPINBUNENGJUJIAOHUOYASUIFUYONG,YINGZHENGLITUNFU。

黑龙江11选5     1、CHENGNIANREN/LAONIANHUANZHEDEYONGYAO:

黑龙江11选5     A、HUODONGXINGSHIERZHICHANGKUIYANGHEHUODONGXINGLIANGXINGWEIKUIYANGHUANZHE:YICI20mg,YIRI1CI,CHENFU。

         DADUOSHUHUODONGXINGSHIERZHICHANGKUIYANGHUANZHEZAIYONGYAO4ZHOUHOUQUANYU。DANYOU2%DEHUANZHEHAIXUYAOJIXUYONGYAO4ZHOUCAINENGQUANYU。

黑龙江11选5          YIXIESHIERZHICHANGKUIYANGHUANZHEYICI10mg,YIRI1CIDEZHILIAOLIANGJIYOUFANYING。

        DADUOSHUHUODONGXINGLIANGXINGWEIKUIYANGXUZAIYONGYAO6ZHOUHOUQUANYU。DANYOU9%DEHUANZHEHAIXUJIXUYONGYAO6ZHOUCAIKEQUANYU。

黑龙江11选5     B、QINSHIXINGHUOKUIYANGXINGDEWEI-SHIGUANFANLIUZHENG(GERD)HUANZHE:YICI20mg,YIRI1CI,LIAOCHENGWEI4~8ZHOU。

黑龙江11选5     C、WEI-SHIGUANFANLIUZHENGDEZHANGQIZHILIAOFANGAN(GERD)DEWEICHIZHILIAO:LIAOCHENGWEI12GEYUE,WEICHIZHILIAOLIANGWEIYICI10mgHUO20mg,YIRI1CI。YIXIEHUANZHEDUIYIRI10mgDEWEICHIZHILIAOLIANGJIYOUFANYING。

黑龙江11选5     D、YOUMENLUOXUANGANJUNDEGENZHIXINGZHILIAO:

黑龙江11选5          YUSHIDANGDEKANGSHENGSUHEYONG,KEGENZHIYOUMENLUOXUANGANJUNYANGXINGDESHIERZHICHANGKUIYANG。

         BENPINYINGZAIZAOCHEN、CANQIANFUYONG,JINGUANYONGYAOSHIJIANJISHESHIDUILEIBEILAZUONAYAOXIAOWUYINGXIANG,DANCIZHONGJIYAOFANGSHIGENGYOULIYUZHILIAODEJINXING。

    2、GANSHENGONGNENGBUQUANHUANZHEDEYONGYAO:

黑龙江11选5     GANSHENGONGNENGBUQUANHUANZHEZAIYONGYAOGUOCHENGZHONGWUXUJINXINGJILIANGDIAOJIE。DANZAIDUIYOUYANZHONGDEGANGONGNENGBUQUANHUANZHEYONGYAOSHI,YINGCANJIAN“BULIANGFANYINGJIZHUYISHIXIANG”。

【BULIANGFANYING】

黑龙江11选5      1.OUJIAN(BULIANGFANYINGFASHENGLVZAI0.1%?5%):GUANGMINXINGFANYING、TOUTONG、EXIN、OUTU、BIANMI、FUZHANG、FUXIE、PIZHEN、QIANMAZHEN;HONGXIBAOJIANSHAO、BAIXIBAOJIANSHAO、BAIXIBAOZENGDUO、SHISUANXINGLIXIBAOZENGDUO、SHIZHONGXINGLIXIBAOZENGDUO、LINBAXIBAOJIANSHAO;ALT、AST、ALP、γ-GTP、LDH、ZONGDANHONGSU、ZONGDANGUCHUN、BUNSHENGGAO;DANBAINIAODENGBULIANGFANYING。

     2. HANJIAN(BULIANGFANYINGFASHENGLVZAI<0.1%):XIUKE、XINJI、XINDONGGUOHUAN、XIAFUTONG、XIAOHUABULIANG、XIONGTONG、JITONG、SHILIZHANGAI、XUANYUN、SHIMIAN、KUNJUAN、JUANDAIGAN、WOLIDIXIA、SIZHIFALI、GANJUECHIDUN、KOUCHIBUQING、BUTAIPANSHAN、RONGXUEXINGPINXUEDENG。CIWAIGUOWAI1LIYOUGANXINGNAOZHENGJIWANGSHIDEGANYINGHUAHUANZHECHUXIANLEJINGSHENCUOLUAN、SHIBIANLISANGSHIHESHISHUI。

黑龙江11选5 【JIN    JI】

     DUILEIBEILAZUONA、BENBINGMIZUODAIXIEWUHUOFULIAOGUOMINZHEJINYONG。

【ZHUYISHIXIANG】

     1. YONGBENPINKAISHIZHILIAOZHIQIANYINGPAICHUCUNZAIAIZHENGDEKENENGXING。JINGUANZAINIANLINGHEXINGBIEPIPEIDEQINGZHONGDUGANZANGSUNSHANGHUANZHEYUZHENGCHANGZHEDEDUIZHAOYANJIUZHONG,WEIJIANDAOMINGXIANYUYAOWUXIANGGUANDEANQUANWENTI,DANSHIZHONGDUGANSUNSHANGHUANZHECHUCISHIYONGBENPINZHILIAOSHI,YISHENGJIANYIYAOTEBIEZHUYI。

     2. FUYONGBENPINSHI,YINGDINGQIJINXINGXUEYEJIANCHAJIXUEYESHENGHUAXUE(RUGANMEIJIANCHA),FAXIANYICHANG,JITINGZHIYONGYAO,BINGJINXINGJISHICHULI。

     3. GANGONGNENGSUNSHANGDEHUANZHESHENYONG。

【YUNFUJIBURUQIFUNVYONGYAO】

     1. DUIYUYUNFUHUOYOUKENENGRENSHENDEFUNV,ZHIYOUZAIQIZHILIAOYOUYIXINGDAYUWEIXIANXINGDEQIANTIXIAFANGKESHIYONG。

     2. BENPINKENENGTONGGUORUZHIFENMI,GUBIMIANYONGYUBURUQIFUNV,BUDEYIERBIXUYONGYAOSHI,ZEYINGZANTINGJIYINGERBURU。

黑龙江11选5 【ERTONGYONGYAO】

黑龙江11选5      MUQIANSHANGWUERTONGFUYONGBENPINDEANQUANXINGHEYOUXIAOXINGZILIAO。

【LAONIANYONGYAO】

     LINCHUANGYANJIUBIAOMING,WEIJIAN65SUIYISHANGHUANZHEYUNIANQINGHUANZHEZAILIAOXIAOYUANQUANXINGFANGMIANYOUCHAYI,DANBUPAICHUMOUXIELAONIANHUANZHEDEMINGANXINGGENGQIANG。YOUYUBENYAOZHUYAOZAIGANZANGDAIXIE,ERLAONIANHUANZHEGANGONGNENGDIXIAZHEJUDUO,YOUSHIKECHUXIANBULIANGFANYING。YINCI,DANGCHUXIANXIAOHUAXITONGBULIANGFANYING(CANZHAO“BULIANGFANYING”XIANG)SHI,YINGJINSHENJIYU,BIYAOSHIYINGTINGZHIYONGYAO。

【YAOWUXIANGHUZUOYONG】

     LEIBEILAZUONATONGGUOXIBAOSESUP450(CYP450)DAIXIEMEIXITONGJINXINGDAIXIE。JIANKANGSHIYANZHEYANJIUBIAOMING,LEIBEILAZUONALINCHUANGSHANGMEIYOUMINGXIANDEYUQITADETONGGUOCYP450XITONGDAIXIEDEYAOWUYOUXIANGHUZUOYONG。

     LEIBEILAZUONANENGGOUCHANSHENGCHIXUXINGDEYIZHIWEISUANFENMIDEZUOYONG。YOUYULEIBEILAZUONASHISUANDUXIAJIANG,YINCI,YUNEIXIEXISHOUYUWEIpHZHIYOUGUANDEYAOWUYOUXIANGHUZUOYONG。LIRU,ZHENGCHANGSHOUSHIZHERUGUOMEITIANTONGSHIFUYONGTONGKANGZUOYU20mgLEIBEILAZUONA,HUISHITONGKANGZUODESHENGWULIYONGDUJIANSHAODAYUE30%;TONGSHIFUYONGDIGAOXIN,HUISHIDIGAOXINDEAUCHECmaxZHIFENBIEZENGJIA19%HE29%。YINCI,BINGRENZAITONGSHIFUYONGSHANGSHUYAOWUHELEIBEILAZUONASHIYINGJINXINGJIANCE。LEIBEILAZUONAYUKANGSUANJITONGSHIFUYONGYIJIZAIFUYONGKANGSUANJI1XIAOSHIHOUZAIFUYONGSHI,LEIBEILAZUONADEPINGJUNXUEJIANGZHONGNONGDUQUXIANXIAMIANJIFENBIEXIAJIANG8%HE6%。BENPINDELEISIYAOWUAOMEILAZUOYUBENTUOYINGTONGFUYOUDAOZHIBENTUOYINGDAIXIEHUOPAIXIEYANHUANDEBAOGAO。

黑龙江11选5 【YAOWUGUOLIANG】

黑龙江11选5       WUYIZHIDETEXIAOJIEDUJI。FUYONGBENPINGUOLIANGSHI,YINGANHUANZHEDELINCHUANGZHENGZHUANGHETIZHENG,CAIYONGSHIDANGDEZHICHILIAOFA。

黑龙江11选5 【YAOLIDULI】

      YAOLIZUOYONG:

      LEIBEILAZUONAWEIBENBINGMIZUOLEIHUAHEWU,SHIDIERDAIZHIZIBENGYIZHIJI,TONGGUOTEYIXINGDIYIZHIWEIBIXIBAOH+, K+-ATPMEIXITONGERZUDUANWEISUANFENMIDEZUIHOUBUZHOU。GAIZUOYONGCHENGJILIANGYILAIXING,BINGKESHIJICHUWEISUANFENMIHECIJIZHUANGTAIXIADEWEISUANFENMIJUNSHOUYIZHI。BENPINDUIDANJIANHEZUANH2SHOUTIWUJIEKANGZUOYONG。

黑龙江11选5  DULIYANJIU:

      YICHUANDUXING:BENPINSHUSHANGHANSHAMENSHIJUNHUIFUTUBIAN(Ames)SHIYAN、ZHONGGUOCANGSHULUANXIBAOJIYINTUSHIYAN、XIAOSHULINBALIUXIBAOJIYINTUBIANSHIYANJIEGUOJUNCHENGYANGXING;QIQUJIAJIDAIXIEWUZAISHIYANZHONGYECHENGYANGXING;BENPINTIWAICANGSHUFEIXIBAORANSETIJIBIANSHIYAN、XIAOSHUWEIHESHIYANHETINEI、TIWAIGANCHENGXUWAIDNAHECHENG(UDS)SHIYANJIEGUOJUNWEIYINXING。

SHENGZHIDUXING:

黑龙江11选5       DASHUJINGMAIJIYULEIBEILAZUONA50mg/kg/RI(XUEJIANGAUCYUEWEIHUANZHELINCHUANGTUIJIANJILIANGSHIDE13BEI)HETUJINGMAIJIYUBENPIN50mg/kg/RI(XUEJIANGAUCYUEWEIHUANZHELINCHUANGTUIJIANJILIANGSHIDE8BEI),QISHENGYULIHESHENGZHIXINGWEIWEIJIANMINGXIANYICHANG,DUIDONGWUTAIZIWEIJIANSUNSHANG。SHANGWUHUAIYUNFUNVJIYAODECHONGFENHEYANGEDUIZHAODELINCHUANGYANJIU,YOUYUDONGWUSHENGZHIDUXINGBINGBUZONGNENGYUCEYAOWUDUIRENTIDEYINGXIANG,GUHUAIYUNQIJIANJINZAIQUESHIXUYAOSHICAINENGSHIYONGBENPIN。

黑龙江11选5 DASHUZAIRENSHENHOUQIHEBURUQIJINGKOUJIYULEIBEILAZUONA0.4g/kg/RI,KEDAOZHIDONGWUTIZHONGZENGZHANGJIANMAN。YOUYUXUDUOYAOWUKEJINGRUZHIFENMI,QIEKENENGDUIBURUYINGERCHANSHENGDUFUZUOYONG,GUYINGKAOLVYAOWUDUIMUQINDEZHONGYAOXING,JUEDINGZAICIQIJIANSHITINGZHIBURUHAISHITINGZHIYONGYAO。

ZHIAIXING:

      CAIYONGCD-1XIAOSHUJINXINGLE88/104ZHOUSHIYAN,LEIBEILAZUONAJINGKOUJIYAOJILIANGGAODA0.1g/kg/RISHIWEIBIAOXIANCHUZHONGLIUFASHENGLVZENGJIA,CISHIXUEYAONONGDUWEIHUANZHETUIJIANJILIANGXIADE1.6BEI。CAIYONGSDDASHUJINXINGLEJIYAO104ZHOUDEZHIAIXINGSHIYANYANJIU,QIZHONGXIONGXINGDASHUKOUFUJILIANG5,15,30,60mg/kg/RI,CIXINGDASHUKOUFUJILIANG5,15,30,60HE120mg/kg/RI,JIEGUOSUOYOUJILIANGZUCI、XIONGDONGWUJUNCHUXIANWEICHANGSHIGEXIBAOYANG(ELC)ZENGSHENG,CIXINGDONGWUSUOYOUJILIANGZUDOUCHUXIANWEICHANGSHIGEXIBAOYANG(ELC)LIANGXINGZHONGLIU。XIONGXINGDONGWUJISHIZAIZUIGAOJILIANGZU(XUEYAONONGDUXIANGDANGYULINCHUANGTUIJIANJILIANGXIADE0.2BEI)XIA,YEWEIJIANYUYAOWUYOUGUANDEZHONGLIUCHANSHENG。

【YAODAIDONGLIXUE】

 JIANKANGCHENGNIANNANZIZAIKONGFUQINGKUANGXIADANCIKOUFUBENJI10mg、20mg、40mgSHIDEYAODAIDONGLIXUECANSHURUXIA:

      雷贝拉唑钠的血浆蛋白结合率约为97%,主要的代谢产物为硫醚(MI)和羧酸(M6)。 次要代谢物还有砜(M2)、乙基硫醚(M4)和硫醚氨酸(M5)。只有乙基代谢物(M3)具有少量抑制分泌的活性,但不存在于血浆中。该药90%主要随尿排出,其它代谢物随粪便排出。在需要血液透析的晚期稳定的肾衰患者体内(肌酐清除率 ≤5ml/min/1.73m2),雷贝拉唑钠的分布与在健康受试者体内的分布相似。此药用于老年患者时,药物清除率有所降低。当老年患者用雷贝拉唑钠20mg,一日1次,连续7日,出现血药浓度的曲线下面积加倍,血药浓度峰值相对于年轻健康受试者升高60%。另外,此药在体内无累积现象。

黑龙江11选5 【ZHU    ZANG】

黑龙江11选5       MIFENG,ZAIYINLIANG(BUCHAOGUO20℃)GANZAOCHUBAOCUN。

【BAO    ZHUANG】

黑龙江11选5       JUXIANAN/LV/JULVYIXILENGCHONGYACHENGXINGGUTIYAOYONGFUHEYINGPIAN、YAOYONGBAOZHUANGLVBOBAOZHUANG;JULVYIXI/JUPIANERLVYIXIGUTIYAOYONGFUHEYINGPIAN、YAOYONGBAOZHUANGLVBOBAOZHUANG

黑龙江11选5       1. 10mg:6LI/BAN,1BAN/HE,2BAN/HE,3BAN/HE;7LI/BAN,1BAN/HE,2BAN/HE,

黑龙江11选5       2. 20mg:6LI/BAN,1BAN/HE, 7LI/BAN,1BAN/HE。

【有 效 期】18个月

【执行标准】《中国药典》2015年版二部及检查项“水分”执行标准YBH09252004-2014Z

【PIZHUNWENHAO】

    (1)10mg:GUOYAOZHUNZIH20040916

黑龙江11选5     (2)20mg:GUOYAOZHUNZIH20061220